Cardiac Safety Applications Using Axiogenesis Cor.4U Cardiomyocytes and the Maestro MEA Platform

Axiogenesis’ Cor.4U are human induced pluripotent stem cell-derived (hiPSC) cardiomyocytes that exhibit typical biochemical, electrophysiological, mechanical, and pathophysiological characteristics of native human cardiac myocytes. Due to their human origin, high-purity, functional relevance, and ease of use, Cor.4U represent an optimal test system for interrogating cardiomyocyte biology in basic research, drug discovery, and safety screening. The Maestro microelectrode array (MEA) platform from Axion Biosystems is a non-invasive, label-free assay that measures activity of electrically-active cells in throughputs up to 96 wells. Cor.4U can be cultured on Axion MEA plates to form a stable syncytium amenable to electrophysiological interrogation. With robust, physiologically-relevant responses, Cor.4U and Axion’s MEA technology together form an innovative platform for in vitro screening of compound effects on human cardiomyocyte physiology.