Assessment of proarrhythmic potential of drugs in optogenetically paced induced pluripotent stem cell-derived cardiomyocytes

Patel D, Stohlman J, Dang Q, Strauss DG, Blinova K.

Toxicol Sci, 2019

Summary:

Read about how researchers used Maestro and Lumos technology to optically pace iPSC-CMs in order to attempt to develop a more efficient way to predict proarrhythmic risk during preclinical drug development.

Keywords: CiPA, optogenetics, pacing, proarrhythmia, Torsade de Pointes, FPD prolongation, cardiotoxicity, safety