Constitutive inactivation of the PRRT2 gene alters short-term synaptic plasticity and promotes network hyperexcitability in hippocampal neurons

Valente P,  Romei A,  Fadda M,  Sterlini B,  Lonardoni D, Forte N,  Fruscione F,  Castroflorio E,  Michetti C,  Giansante G, Valtorta F,  Tsai JW,  Zara F,  Nieus T,  Corradi A,  Fassio A, Baldelli P,  Benfenati F.

Cerebral Cortex, 2018

Summary:

Explore how Maestro MEA technology helped to produce data that indicates the existence of network instability/hyperexcitability as the possible basis of the paroxysmal phenotype associated with PRRT2 mutations.