Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL.
Hum Mol Genetics, 2014
Summary:
This paper evaluates the generation of inducible pluripotent stem cell lines from patients with familial Alzheimer's disease with amyloid precursor protein mutation. Differentiation over time was evaluated and neuronal fates showed spontaneous activity on microelectrode array (MEA) plates. The induced neuronal cells with the mutation showed increased Tau levels and that Aβ-specific antibodies early in culture could reduce this phenotype.
Keywords: Alzheimer's disease, neurodegenerative disorder, extracellular plaques, amyloid, Tau protein
The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
