Impact of sleep-wake-associated neuromodulators and repetitive low-frequency stimulation on human iPSC-derived neurons

Yokoi R, Okabe M, Matsuda N, Odawara A, Karashima A, Suzuki I.

Front Neurosci, 2019

Summary:

Explore how Maestro MEA technology helped to show that sleep-wake states can be mimicked by cyclic neuromodulator administration and that LTD-like phenomena can be induced by LFS in vitro human iPSC-derived neurons. 

Keywords: circadian rhythms, neurotransmitters, low-frequency stimulation, REM, long-term depression, wake, brain wave, sleep homeostasis, serotonin, acetylcholine, histamine, orexin, noradrenaline, dopaminergic