Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic controls

Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA.

eLife, 2019

Summary:

Researchers used the Maestro MEA to understand the basis of hyperactivity in hiPSC-derived cerebrocortical neuronal cultures and cerebral organoids with AD-related mutations.  

Keywords: Mini-brains, Alzheimer's disease, AD, cerebral organoid, spheroid, amyloid precursor protein, synaptic disfunction, neurodegeneration