Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

Moyer BD, Murray JK, Ligutti J, Andrews K, Favreau P, Jordan JB, Lee JH, Liu D, Long J, Sham K, Shi L, Stöcklin R, Wu B, Yin R, Yu V, Zou A, Biswas K, Miranda LP.

PLoS One, 2018

Summary:

Discover how Maestro technology helped researchers discover new and potent engineered Nav1.7 inhibitory peptides that have improved Nav selectivity and biological activity in blocking action potential firing in both DRG neurons and C-fibers.