Resilience to pain: A peripheral component identified using induced pluripotent stem cells and dynamic clamp

Mis MA, Yang Y, Tanaka BS, Gomis-Perez C, Liu S, Dib-Hajj F, Adi T, Garcia-Milian R, Schulman BR, Dib-Hajj SD, Waxman SG.

J Neurosci, 2018

Summary:

See how Maestro technology helped researchers show that subject-specific iPSCs can be used to model inter-individual differences in pain, and provide proof-of-principle that iPSCs, WES, and dynamic clamp can be used to investigate peripheral mechanisms and pinpoint specific gene variants that modulate pain signaling.

Keywords: nociceptor, pain, peripheral nerve, dorsal root ganglion, drg