REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

Pozzi D, Lignani G, Ferrea E, Contestabile A, Paonessa F, D'Alessandro R, Lippiello P, Boido D, Fassio A, Meldolesi J, Valtorta F, Benfenati F, Baldelli P.

EMBO J, 2013

Summary:

In this paper, activation of REST/NRSF in cultured hippocampal neurons was shown to downregulate the firing activity at the single-cell level and maintain physiological spiking within the neural network.  Therefore, REST/NRSF is suggested to play a factor in intrinsic homeostatis of the neuronal network. 

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability