Super-obese patient-derived iPSC hypothalamic neurons exhibit obesogenic signatures and hormone responses

Rajamani U, Gross AR, Hjelm BE, Sequeira A, Vawter MP, Tang J, Gangalapudi V, Wang Y, Andres AM, Gottlieb RA, Sareen D.

Cell Stem Cell, 2018

Summary:

Discover how Maestro technology helped researchers use differentiated hypothalamic-like neurons (iHTNs) derived from normal and obese patients to show how these cells provide a powerful platform to study obesity and gene-environment interactions. 

Keywords: obesity, ghrelin, leptin, hypothalamic neuron, neuropeptides, axonal guidance, glutamate receptors, endoplasmic reticulum, gene-environment interaction, transcriptomic