Supramolecular nanostructure activates TrkB receptor signaling of neuronal cells by mimicking brain-derived neurotrophic factor

Edelbrock AN, Alvarez Z, Simkin D, Fyrner T, Chin SM, Sato K, Kiskinis E, Stupp SI.

Nano Lett, 2018

Summary:

See how Maestro MEA technology helped scientists discover a new strategy that has the potential to induce endogenous cell infiltration and promote functional neuronal maturation through the presentation of the BDNF mimetic signal. 

Keywords: BDNF, neurotrophin, tyrosine kinase B, TrkB, differentiation, maturation, synaptic plasticity, nanostructure