Synergistic effects of common schizophrenia risk variants

Schrode N, Ho SM, Yamamuro K, Dobbyn A, Huckins L, Matos MR, Cheng E, Deans PJM, Flaherty E, Barretto N, Topol A, Alganem K, Abadali S, Gregory J, Hoelzli E, Phatnani H, Singh V, Girish D, Aronow B, Mccullumsmith R, Hoffman GE, Stahl EA, Morishita H,, Sklar P, Brennand KJ

Nat Genet, 2019

Summary:

Explore how Axion Maestro MEA technology enhances research using hiPSC neurons with CRISPR editing to evaluate the effects of schizophrenia-associated common variants.

Keywords: schizophrenia, CRISPR, presynaptic, postsynaptic, gene expression, synaptic function, psychiatric disorder