Abstract:
Pluricyte® Cardiomyocytes are highly suitable for Axion Maestro MEA assays
Pluricyte® Cardiomyocytes are fully functional human-induced pluripotent stem cell (hiPSC) derived ventricular cardiomyocytes that are particularly suitable for electrophysiology-based microelectrode array (MEA) assays for predictive safety pharmacology, toxicity testing and efficacy screening in early drug discovery and development. Pluricyte® Cardiomyocytes’ well-pronounced depolarization and repolarization peaks permit the easy detection of electrophysiological parameters (e.g. depolarization/repolarization peak amplitudes, beat rate, field potential duration) and facilitate efficient data analysis and interpretation of studies performed with the Axion Maestro MEA system. The combination of Pluricyte® Cardiomyocytes with the Axion Maestro MEA system enables detailed electrophysiological detection of cardioactive/proarrhythmic effects of test compounds at 48- or 96-well plate formats.
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