Authors: Wlodkowic D, Bownik A, Leitner C, Stengel D, and Braunbeck T.
Science of the Total Environment, 2022.
Scientists use Axion’s noninvasive, label-free platform to examine neuronal transmission in zebrafish larvae in situ
Eco-neurotoxicity risks from aquatic pollution are typically assessed in animals by observing behavioral phenotypes including locomotion, mating, and feeding, but little is known about the cellular and physiological mechanisms underlying these activities. In this review, scientists argue that while behavioral phenotyping is valuable, investigating the underlying mechanisms related to neurotoxic and neuromodulating contaminants should not be overlooked. The team also explores applications and strategies such as multielectrode array (MEA) recordings “that should be embraced and more broadly adopted in behavioral ecotoxicology.” As an example, the researchers used Axion’s noninvasive, label-free Maestro MEA platform to perform a real-time functional analysis of neuronal transmission in zebrafish larvae in situ and suggest that this technique may be used with diverse aquatic species including invertebrates. This innovative application of MEA technology, along with other testing methods, highlights the scientists’ efforts to uncover the mechanisms underlying phenotypic behaviors and provide new insights in the field of ecotoxicology.
