Combining NGN2 programming with developmental patterning generates human excitatory neurons with NMDAR-mediated synaptic transmission

Nehme R, Zuccaro E, Ghosh SD, Li C, Sherwood JL, Pietilainen O, Barrett LE, Limone F, Worringer KA, Kommineni S, Zang Y, Cacchiarelli D, Meissner A, Adolfsson R, Haggarty S, Madison J, Muller M, Arlotta P, Fu Z, Feng G, Eggan K.

Cell Rep, 2018

Summary:

Discover how Maestro technology was used with single-cell and reporter gene approaches to select well-differentiated neurons for study, greatly enhancing the utility of programmed neuronal populations in the modeling of nervous system disorders.