Comparative analysis of media effects on human induced pluripotent stem cell-derived cardiomyocytes in Proarrhythmia risk assessment

Schocken D, Stohlman J, Vicente J, Chan D, Patel D, Matta MK, Patel V, Brock M, Millard D, Ross J, Strauss DG, Blinova K.

J Pharmacol Toxicol Methods, 2017

Summary:

Axion's microelectrode array system recorded the effects of 25 drugs (both serum-containing and serum-free) on the spontaneous field potentials and prevalence of arrhythmic events in iPSC-CM's. The media formulations influenced the baseline electrophysiological properties and compound availability.