Comparative analysis of media effects on human induced pluripotent stem cell-derived cardiomyocytes in Proarrhythmia risk assessment

Authors: Derek Schocken, Jayna Stohlman, Jose Vicente, Dulciana Chan, Dakshesh Patel, Murali Krishna Matta, Vikram Pate, Mathew Brock, Daniel Millard, James Ross, David G. Strauss, and Ksenia Blinova

Journal of Pharmacological and Toxicological Methods, 16 November 2017

Axion's Maestro microelectrode array (MEA) system recorded the effects of 25 drugs (both serum-containing and serum-free) on the spontaneous field potentials and prevalence of arrhythmic events in iPSC-CM's. The media formulations influenced the baseline electrophysiological properties and compound availability.