Gad AA, Azimzadeh P, Balenga N.
Scientific Reports, 2021
Summary:
G protein-coupled receptors (GPCRs) play important roles in various cellular kinetic processes such as cell proliferation, neurotransmission, contraction and more. Adhesion GPCRs are the second largest family of GPCRs and play a role in endocrine, immune and nervous systems.
The Maestro Z impedance assay was used to non-invasively, label-free evaluate the whole cell response to detect the 'overall' response to the GPCR ligands. The resulting data confirmed the lack of receptor activation by Stachel peptide with ECL2 mutations.
