Furkan Bestepe, Colette Fritsche, Kartik Lakhotiya, Carolyn E. Niosi, George F. Ghanem, Gregory L. Martin, Ruma Pal-Ghosh, Dakota Becker-Greene, James Weston, Ivana Hollan, Ivar Risnes, Stein Erik Rynning, Liv Heidi Solheim, Mark W. Feinberg, Robert M. Blanton, Basak Icli
Molecular Therapy, Volume 32, P995-1009, June 13, 2023
This study investigated the metabolic regulation of miR-409-3p using an acute myocardial infarcation (MI) mouse model. The Omni BR was facilitated to investigate the impact of a miR-409-3p mimic, inhibitor and control, on endothelial cell (EC) migration in a wound. The wound was made by growing cells full monolayer and scratched using a 200 mL micropipette tip, and cell migration and therefore wound closure were validated. This study concluded that miR-409-3p mimic inhibited EC migration, whereas miR-409 inhibitors increased EC growth, solidifying its role as a potent anti-angiogenic miRNA.
