Engineered cardiac pacemaker nodes created by TBX18 gene transfer overcome source-sink mismatch

Grijalva SI, Gu J, Li J, Fernandez N, Fan J, Sung JH, Lee SY, Herndon C, Buckley EM, Park SJ, Fenton FH, Cho HC.

Adv Sci, 2019

Summary:

Discover how Maestro technology aided researchers in evaluating how induced TBX18 cardiac pacemaker cells in spheriods can pace autonomously and drive contraction.

Keywords: sinoatrial node, cardiac pacemaker, TBX18, cardiac spheroids, cardiac organoids, myocardium, beta-adrenergic