Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson's disease models

Song B, Cha Y, Ko S, Jeon J, Lee N, Seo H, Park KJ, Lee IH, Lopes C, Feitosa M, Luna MJ, Jung JH, Kim J, Hwang D, Cohen BM, Teicher MH, Leblanc P, Carter BS, Kordower JH, Bolshakov VY, Kong SW, Schweitzer JS, Kim KS.

J Clin Invest, 2020

Summary:

MicroRNA reprogramming factors and novel in vitro differentiation methodology generated functional and healthy dopamine neurons. This method presents a scalable, safe and effective method of producing autologous neurons that secrete dopamine, and exhibit typical electrophysiology.