Authors: Lora-Sophie Gerber, Dirk C.A. de Leijer, Andrea Rujas Arranz, Jonas M.M.L. Lehmann, Meike E. Verheul, Flemming R. Cassee, and Remco H.S. Westerink
Environment International, 5 February 2024
Scientists use Maestro Pro MEA to assess the neurotoxicity of particulate matter in vitro.
Research has demonstrated that particulate matter (PM) from diesel engine emission has adverse effects on the brain, but direct PM-induced effects on neuronal function and in the lungs are unclear. In this study, scientists explore potential lung and neurotoxicity of particulate matter derived from both regular fossil diesel (PMDEP) and biodiesel (PMBIO) combustion, compared to clean carbon particles.
Using Axion’s noninvasive Maestro Pro multielectrode array (MEA) platform, the team demonstrated that both PMDEP and PMBIO induced neurotoxicity following direct exposure, though this effect was absent after simulated inhalation, suggesting the lungs help serve as a protective barrier. PMDEP was also found to be more potent than PMBIO. According to the authors, “This is the first study using a novel integrated in vitro approach to study the indirect (systemic) effects of particles on brain function,” offering important insights on neurotoxicity.
