Authors: Elixirgen Scientific
Neurotoxicity is a major cause of failures in drug development. Animal models have been insufficient for precise prediction of neurotoxicity because of the species difference. To overcome this difficulty human neurons generated from induced pluripotent stem cell (iPSC) have been extensively tested. A major assay system for this purpose is neuronal networks cultured on microelectrode arrays (MEAs). In this paper we investigated whether Quick-Neuron TM Excitatory (EX-SeV-CW50065) generated with the recently developed quick differentiation method (Quick-TissueTM technology ) are suited to neurotoxicological assays. In addition, we optimized the fabrication and culturing to enable transportation of live-cell MEAs.
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