Authors: Prudencio TM, Swift LM, Guerrelli D, Cooper B, Reilly M, Ciccarelli N, Sheng J, Jaimes R, and Posnack NG.
Toxicological Sciences, 2021
Summary
Scientists use bioelectronic assays to explore cardiotoxicity associated with bisphenol analogs
Research has demonstrated links between bisphenol A (BPA) and health conditions including cardiovascular disease and neurodevelopmental disorders, prompting scientists to explore structural analogs to replace the ubiquitous manufacturing chemical. In this study, researchers examine the effects of BPA alternatives bisphenol S (BPS) and bisphenol F (BPF) on cardiac electrophysiology.
To assess cardiac activity, the team measured human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and intact whole rat heart preparations on Axion’s Maestro multielectrode array (MEA) platform. Findings from MEA and other testing showed that while BPA and BPF exerted an immediate inhibitory effect on cardiac ion channels, BPS was less potent. The authors suggest that additional studies are needed to better understand the cardiotoxic effects of bisphenol analogs.
