miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advances towards Quick Screening for Neuronal Disease Phenotypes In Vitro

Ishikawa M, Aoyama T, Shibata S, Sone T, Miyoshi H, Watanabe H, Nakamura M, Morota S, Uchino H, Yoo AS, Okano H.

Cells, 2020

Summary:

miRNAs are used as reprogramming effectors to directly differentiate fibroblasts to neurons and then applied to iPSCs from Alzheimer's patients.

Keywords: microRNA, neurogenin2, presenilin1, presenilin2, Alzheimer's disease, AD, amyloid beta