Using a Supramolecular Monomer Formulation Approach to Engineer Modular, Dynamic Microgels, and Composite Macrogels

Authors: Maritza M. Rovers, Theodora Rogkoti, Bram K. Bakker, Kalpit J. Bakal, Marcel H.P. van Genderen, Manuel Salmeron-Sanchez, and Patricia Y.W. Dankers

Advanced Materials, 27 October 2024

Hydrogels are widely used as biomaterials but often exhibit isotropic characteristics. In this study, the authors employ supramolecular chemistry to create dynamic microgels held together exclusively by non-covalent interactions, using the Lux3 FL live-cell imaging system to perform time-lapse imaging of normal human dermal fibroblasts (NHDFs) seeded on the created microgels straight from the incubator. The innovative approach described in this paper allows for the engineering of microgels with tunable properties, potentially advancing applications in drug delivery, tissue engineering, and responsive materials.