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Scientists use Axion’s Maestro platform to investigate the role of MYT1L in autism spectrum disorders in vitro and uncover potential new therapeutic pathways.
Publication
MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention
Author: Bettina Weigel, Jana F. Tegethoff, Sarah D. Grieder, Bryce Lim, Bhuvaneswari Nagarajan, Yu-Chao Liu,
Jule Truberg, Dimitris Papageorgiou, Juan M. Adrian-Segarra, Laura K. Schmidt, Janina Kaspar, Eric Poisel,
Elisa Heinzelmann, Manu Saraswat, Marleen Christ, Christian Arnold, Ignacio L. Ibarra, Joaquin Campos,
Jeroen Krijgsveld, Hannah Monyer, Judith B. Zaugg, Claudio Acuna and Moritz Mall
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
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Publication
A Robust Pipeline for the Multi-Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells
Author: D Whye, D Wood, WA Saber, EM Norabuena, NR Makhortova, M Sahin, ED Buttermore
Product: Maestro Pro,
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Publication
Disruption of DDX53 coding sequence has limited impact on iPSC-derived human NGN2 neurons
Author: M Faheem, E Deneault, R Alexandrova, DC Rodrigues, G Pellecchia, C Shum, M Zarrei, A Piekna, W Wei, JL Howe, B Thiruvahindrapuram, S Lamoureux, PJ Ross, CA Bradley, J Ellis, SW Scherer
Product: Maestro Edge,
Advanced Healthcare Materials, Feb 2023
Publication
Deciphering the heterogeneity landscape of mesenchymal stem/stromal cell-derived extracellular vesicles for precise selection in translational medicine
Author: Y. Li, Y. H. Chen, B. Y. Liu, Q. Nie, L. J. Li, X. Duan, L. Z. Wu, and G. Chen
Product: Lux,
Cell Reports, 06 February 2023
Publication
Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF
Author: A. Antoniou, L. Auderset, L. Kaurani, E. Sebastian, Y. Zeng, M. Allahham, S. Cases-Cunillera, S. Schoch, J. Gründemann, A. Fischer, and A. Schneider
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Polymers, 4 February 2023
Publication
Chitin-Glucan Complex Hydrogels: Physical-Chemical Characterization, Stability, In Vitro Drug Permeation, and Biological Assessment in Primary Cells
Author: D. Araújo, T. Rodrigues, C. Roma-Rodrigues, V. D. Alves, A. R. Fernandes, and F. Freitas
Product: Lux, Scratch Assay Module,
FEBS Letters, 03 February 2023
Publication
Cofilin promotes vasculogenic mimicry by regulating the actin cytoskeleton in human breast cancer cells
Author: M. Nakajima, R. Kawahara, and S. Simizu
Product: Lux,
Axion BioSystems Logo
News
Market Disruptor Axion BioSystems Rejects Agilent Technologies, Inc. Allegations
Author: Axion BioSystems
Product:
Omni Brochure
Product Brochure
Omni Brochure
Author: Axion BioSystems
Product: Omni Pro 12, Omni,
Omni Pro 12 press release
News
Axion BioSystems Launches New High-Throughput Live-Cell Imaging Platform, Omni Pro 12
Author: Axion BioSystems
Product: Omni Pro 12,
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Publication
PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux
Author: H Ben-Zvi, T Rabinski, R Ofir, S Cohen, GD Vatine
Product: Maestro Edge, Neural Module,
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Publication
Curcumin, a dietary natural supplement, prolongs the action potential duration of KCNE1-D85N–induced pluripotent stem cell–derived cardiomyocytes
Author: K Martinez, A Smith, D Ye MD, W Zhou MD, DJ Tester BS, MJ Ackerman MD, PHD
Product: Maestro Pro, Cardiac Module,
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Publication
PKM2 deficiency exacerbates gram-negative sepsis-induced cardiomyopathy via disrupting cardiac calcium homeostasis
Author: L Ni, B Lin, M Shen, C Li, L Hu, F Fu, L Chen, J Yang, D Shi
Product: Maestro Pro, Maestro Edge, Cardiac Module,
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Publication
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
Author: Z Álvarez, JA Ortega, K Sato, IR Sasselli, AN Kolberg-Edelbrock, R Qiu, KA Marshall, TP Nguyen, CS Smith, KA Quinlan, V Papakis, Z Syrgiannis, NA Sather, C Musumeci, E Engel, SI Stupp, E Kiskinis
Product: Neural Module,
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Publication
Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues
Author: F Limone, I Guerra San Juan, JM Mitchell, JLM Smith, K Raghunathan, D Meyer, S Dia Ghosh, A Couto, JR Klim, BJ Joseph, J Gold, CJ Mello, J Nemesh, BM Smith, M Verhage, SA McCarroll, O Pietiläinen, R Nehme, K Eggan
Product: Neural Module,
Maestro and Omni Live Cell Platforms
News
CytoSMART Technologies joins the Axion BioSystems brand
Author: Axion BioSystems
Product: Omni, Maestro Z, Maestro Pro,
App Note glycostem NK cell and glioblastoma
Application Note
Quantifying NK-mediated Cytolysis of Glioblastoma in vitro with Maestro Z
Author: Axion BioSystems (data provided by Glycostem Therapeutics)
Product: Maestro Z, Impedance Module, CytoView-Z Plate,
Glia 2022 publication on diminished motor neuron activity after lentivifal SMN delivery
Publication
Diminished motor neuron activity driven by abnormal astrocytic GLAST glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery
Author: Welby E, Ebert AD.
Product: Neural Module,
Applied Sciences, 12 January 2023
Publication
An In Vitro Study of the Healing Potential of Black Mulberry (Morus nigra L.) Extract in a Liposomal Formulation
Author: A. R. Memete, F. Miere, V. Laslo, C. Purcarea, L. Vicas, M. Ganea, A. Antonescu and S. I. Vicas
Product: Lux, Scratch Assay Module,
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Publication
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome
Author: BK Unda, L Chalil, S Yoon, S Kilpatrick, C Irwin, S Xing, N Murtaza, A Cheng, C Brown, A Afonso, E McCready, GM Ronen, J Howe, A Caye-Eude, A Verloes, BW Doble, L Faivre, A Vitobello, SW Scherer, Y Lu, P Penzes, KK Singh
Product: Maestro Pro, Neural Module, CytoView MEA Plate,